C1801
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 | Immunohistochemistry Human ovarian tumor stained with Monoclonal Anti-pan Cytokeratin, clone PCK-26 (Cat. No. C1801) at a 1:300 dilution using DAB as a substrate and hematoxylin as a counterstain, 20x magnification. From Katy Milne, Nelson Lab, Deeley Research Centre, BC Cancer Agency, Victoria, BC. |
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C1801
Sigma
Monoclonal Anti-Cytokeratin, pan antibody produced in mouse
clone PCK-26, ascites fluid
| Synonym: | Monoclonal Anti-Pan Cytokeratin |
Description
| Immunogen | cytokeratin from human epidermis. |
| Specificity | The antibody recognizes an epitope located on the Type II cytokeratins 1, 5, 6, and 8. PCK-26 is a broad spectrum antibody which reacts specifically with a variety of normal, reactive, and neoplastic epithelial tissues. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia. |
Properties
| antibody form | ascites fluid |
| clone | PCK-26 (monoclonal) |
| contains | 15 mM sodium azide |
| species reactivity | lizard, goat, bovine, human, hamster, rat, carp, guinea pig, pig, rabbit, mouse, sheep, chicken, feline, canine, snake |
| application(s) | immunoblotting: suitable |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable | |
| immunohistochemistry (frozen sections): suitable | |
| indirect immunofluorescence: 1:300 using formalin-fixed, paraffin-embedded sections of human or animal tissues | |
| isotype | IgG1 |
| Gene Information | human ... KRT1(3848), KRT5(3852), KRT6A(3868), KRT6B(3854), KRT8(3856) |
| rat ... Krt2-5(369017), Krt2-8(25626) | |
| mouse ... KRT1(16678), Krt5(110308), Krt6a(16687), Krt6b(16688), Krt8(16691) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | 3 |
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References
| reference | Hasan, A., et al., Identification of cytokeratin 1 as a binding protein and presentation receptor for kininogens on endothelial cells Proc. Natl. Acad. Sci. U. S. A. 95, 3615-3620, (1998) Abstract |
| Lane, E.B., et al., A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering. Nature 356, 244, (1992) |
